NIH has made sections for a reason. There in fact may be many reasons. One of them is to make it easier for you, young Padwan, to convey your ideas to the reviewers and to the people Making Decisions about funding. In fact the sections labeled "Innovation" and "Significance" in the proposal correspond to sections that are criteria for assessing a proposal. (Remember, five sections: Significance, Investigators, Innovation, Approach, Environment). Remember the instructions NIH gives me, the reviewer are available to you the writer. Read them.
Pro Tip: in your section titled "INNOVATION" have a single, summary sentence that starts "This proposal [or the project proposed here] is innovative because_________.
Corollary to said tip: In your "SIGNIFICANCE" section have a sentence that starts "The significance of this project lies in ___________. "
If you make me look for it, I may not find it. Possibly one of the most damning things in a review: It is difficult to determine the innovation in this proposal, because X (intervention proposed) is not novel, nor is the use of Y (method for assessing intervention) for disease QQ. Except of course, you had something else in mind as the innovation, and I could not find it. Some reviewers will look, and others will not. Tell them what you want them to know about what you are doing.