Yes, there are little ones and loved ones and old ones who giving even just a little something to will make a huge difference in their life. And, for them, nobody else will.
But, there are other kids with great needs. We all talk the talk about the tax bill, etc.
I challenge to walk the walk and make a difference.
There are many lists of worthy places. Nicholas Kristof always has good ideas. Here's a bit about how to donate effectively (although I don't agree with all of it). Here's a link to his annual giving column.
And here's one of my favorites (h/t @drugmonkeyblog): Donor's Choice. It is a clearinghouse of projects for schoolkids. You can pick an area, you pick high risk or urgent projects. You can pick science or government or phys ed. The requests are itemized to what the teacher needs. You give money, and Donor's Choice fulfills the order and sends it to the school & teacher directly. They are committed to transparency and integrity. They are Good People.
And here's the picture of all the thankyou notes I got, taped up on my office door.