Someone asked me about whether to publish in journal A or journal B. How it would impact their tenure decision. I know there are lots of debates about IF, and glamour journals, etc. I know that there is a difference in publishing in a clinical-oriented vs. basic science-oriented journal. But I can't help but think of an old George Carlin quote:
They show you how detergents take out bloodstains. I think if you’ve got a t-shirt with bloodstains all over it, maybe your laundry isn’t your biggest problem.